| 摘要 |
The present invention provides, among other things, methods and compositions for treating brain-derived neurotrophic factor (BDNF)-related conditions. In some embodiments, the methods include administering to a subject suffering form or susceptible to a BDNF-related condition an angiotensin(1-7) peptide, including both linear and/or cyclic peptides, functional equivalents, analogs and/or derivatives thereof and/or a non-peptidic angiotensin (1-7) receptor agonist. The present invention is based, in part, on the surprising discovery that angiotensin (1-7) peptides can stimulate the production of BDNF in neuronal and endothelial cells. |
