BIOMARKERS FOR INCREASED RISK OF DRUG-INDUCED OSTEONECROSIS OF THE JAW

摘要

The present disclosure provides a method for predicting the risk of a patient for developing adverse drug reactions, particularly drug-induced osteonecrosis of the jaw (ONJ). The disclosure also provides a method of identifying a subject afflicted with, or at risk of, developing ONJ. In some aspects, the methods comprise analyzing at least one genetic marker, wherein the presence of the at least one genetic marker indicates that the subject is afflicted with, or at risk of, developing ONJ.

主权项

1. A method of identifying a subject afflicted with, or at risk of, developing osteonecrosis of the jaw (ONJ), the method comprising:
(a) obtaining a nucleic acid-containing sample from the subject; and (b) analyzing the sample to detect the presence of at least one genetic marker, wherein the presence of the at least one genetic marker indicates that the subject is afflicted with, or at risk of, developing ONJ.