主权项 |
1. A pharmaceutical composition comprising
(i) a transient receptor potential ankyrin-1 (“TRPA1”) antagonist compound selected from a group consisting of N-{4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)acetamide; 4-(2,4-difluoro-3-(trifluoromethyl)phenyl)-2-((2-(2,5,7-trimethyl-4,6-dioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-3-yl)acetyl)imino)thiazol-3(2H)-yl)methyl dihydrogen phosphate; and a pharmaceutically acceptable salt thereof, and (ii) an analgesic agent, wherein the TRPA1 antagonist and the analgesic agent are present in a weight ratio ranging from about 1:0.001 to about 1:800. |