A method for producing a template of a binding site of a target protein is provided. A target protein is modeled in silico. A binding site is hydrated with water molecules by finding areas within the binding site where water molecules remain localized during a molecular dynamic simulation. Interactions of the water molecules with the hydration sites are classified as a hydrogen bond acceptor interaction (A) or a hydrogen bond donor interaction (D). The classified interactions are mapped to provide a template of hydrogen bond interactions with the protein.
申请公布号
WO2015054222(A1)
申请公布日期
2015.04.16
申请号
WO2014US59456
申请日期
2014.10.07
申请人
RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEWYORK;KOREA UNIVERSITY