| 发明名称 |
CARRIERS FOR IMPROVED DRUG DELIVERY |
| 摘要 |
The invention provides carriers that enhance the absorption, half-life or bioavailability of therapeutic compounds. The carriers comprise targeting groups that bind the Vitamin D Binding protein (DBP), conjugation groups for coupling the targeting groups to the therapeutic compounds, and optionally scaffolding moieties. |
| 申请公布号 |
US2015104469(A1) |
申请公布日期 |
2015.04.16 |
| 申请号 |
US201314401519 |
申请日期 |
2013.03.14 |
| 申请人 |
Extend Biosciences, Inc. |
发明人 |
Soliman Tarik;Hales Laura M.;Sard Howard P.;Amere Mukkanti |
| 分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A carrier-drug conjugate, comprising
a targeting group comprising vitamin D, an analog or metabolite thereof, that is not hydroxylated at the Carbon 1 position linked to a therapeutic peptide or a therapeutic nucleic acid. |
| 地址 |
Cambridge MA US |
