一种ＪＡＫ激酶抑制剂的硫酸氢盐及其制备方法;BISULFATE OF JAK KINASE INHIBITOR AND PREPARATION METHODS THEREOF

摘要

本发明涉及一种JAK激酶抑制剂的硫酸氢盐及其制备方法。更具体地，本发明涉及如式(I)所示的(3aR,5s,6aS)-N-(3-甲氧基-1,2,4-噻二唑-5-基)-5-(甲基(7H-吡咯并[2,3-d]嘧啶-4-基)胺基)六氢环戊并[c]吡咯-2(1H)-甲醯胺硫酸氢盐及其制备方法和用途。如式(I)所示的硫酸氢盐可很好地作为JAK激酶抑制剂应用于临床，用来治疗风湿及类风湿性关节炎。;The present invention relates to bisulfate of JAK kinase inhibitor and preparation methods thereof. Specifically, the present invention relates to (3aR,5s,6aS)-N-(3-methoxy-1,2,4-thiadiazol-5-yl)-5-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxamide bisulfate of general formula (I), preparation methods thereof and pharmaceutical use. The bisulfate of general formula (I) can be well used as JAK kinase inhibitors in clinical application and treatment of rheumatism and rheumatoid arthritis.