SUSCEPTIBILITY TO AND STRATIFICATION FOR MONOAMINERGIC ANTIDEPRESSANTS
摘要
The present invention relates to a method for predicting the non-response or response to a monoaminergic antidepressant of a patient to be treated with a monoaminergic antidepressant comprising the steps: (i) determining the DNA-methylation status of a brain-derived neurotrophic factor (BDNF)-gene promoter in a sample of said patient; (ii) attributing a hypomethylation of said BDNF-gene promoter to the non-response to a monoaminergic antidepressant of said patient; and (iii) attributing normal methylation or hypermethylation of said BDNF-gene promoter to the response to a monoaminergic antidepressant of said patient. Furthermore, a kit and the use of a kit in said method is disclosed.
申请公布号
EP2859353(A1)
申请公布日期
2015.04.15
申请号
EP20130727065
申请日期
2013.05.08
申请人
MEDIZINISCHE HOCHSCHULE HANNOVER;UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ
发明人
FRIELING, HELGE;TADIC, ANDRÉ;BLEICH, STEFAN;LIEB, KLAUS J.