INHIBITORS OF 17ß-HSD1, 17ß-HSD3 AND 17ß-HSD10

摘要

The present application discloses 17&bgr; hydroxy steroid dehydrogenase (17&bgr; HSD) type 1, 3, 10 inhibitors and use thereof (alone and in combination) in the treatment of cancer and other afflictions. 17&bgr; HSD1 inhibitors include estradiol derivatives with a nieta-carbamoylbenzyl substituent at C 16. 17&bgr; HSD3/HSD10 inhibitors include androsterone derivatives substituted at the C3 position with a sulfonamide piperazine. Also disclosed are compounds that are inhibitors of both 17&bgr; HSD1 and 17&bgr; HSD3 that have a spiro-morpholine substituent at C20.