| 发明名称 |
Method for producing nucleic acid base having perfluoroalkyl group |
| 摘要 |
<p>Provided is a simple and efficient production process of a nucleobase having a perfluoroalkyl group. A nucleobase (for example, uracils, cytosines, adenines, guanines, hypoxanthines, xanthines, or the like) is reacted with a perfluoroalkyl halide in the presence of a sulfoxide, a peroxide and an iron compound to produce a perfluoroalkyl-substituted nucleobase, which is useful as an intermediate for medical drugs, economically.</p> |
| 申请公布号 |
EP1947092(B1) |
申请公布日期 |
2015.04.15 |
| 申请号 |
EP20060823008 |
申请日期 |
2006.11.06 |
| 申请人 |
TOSOH CORPORATION;TOSOH F- TECH INC.;SAGAMI CHEMICAL RESEARCH CENTER |
发明人 |
YAMAKAWA, TETSU;YAMAMOTO, KYOKO;URAGUCHI, DAISUKE;TOKUHISA, KENJI |
| 分类号 |
C07D239/54;C07D239/22;C07D473/04;C07D473/08;C07D473/10;C07D473/12;C07D473/16;C07D473/18;C07D473/30;C07D473/34;C07H19/067;C07H19/073;C07H19/167 |
主分类号 |
C07D239/54 |
| 代理机构 |
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