发明名称 |
ANTIGEN-BINDING MOLECULE FOR PROMOTING CLEARANCE FROM PLASMA OF ANTIGEN COMPRISING SACCHARIDE CHAIN RECEPTOR-BINDING DOMAIN |
摘要 |
Disclosed are an antigen-binding molecule containing a sugar chain receptor-binding domain and having a weak antigen-binding activity in the pH of early-stage endosome compared to the antigen-binding activity in the pH of plasma; a pharmaceutical composition containing the antigen-binding molecule; and a method for producing these. Use of the antigen-binding molecule of the invention enables to promote uptake of an antigen into a cell and increase the number of antigens that a single antibody molecule can bind. Administration of the antibody enables to reduce the number of antigens in plasma more and more and improve pharmacokinetics of the antibody. |
申请公布号 |
EP2765192(A4) |
申请公布日期 |
2015.04.15 |
申请号 |
EP20120838341 |
申请日期 |
2012.10.05 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
IGAWA, TOMOYUKI;TAMBA, SHIGERO;KAWAZOE, MEIRI |
分类号 |
C12N15/09;A61K39/00;A61K39/395;C07K16/18;C12P21/02;C12P21/08;C12Q1/02 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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