发明名称 |
TWO PHASE PHARMACEUTICAL DELIVERY SYSTEM |
摘要 |
A bi-phasic pharmaceutical composition for oral administration including one or more solid active ingredient containing particles dispersed within a semi-solid carrier formulation. The solid particles include a coating with pH-triggered drug release properties and the semi-solid carrier formulation is formulated at a pH that is different than the pH at which the active ingredient release properties of the coating are triggered. Also described is a delivery system for delivery of the bi-phasic pharmaceutical composition including the bi-phasic pharmaceutical composition described above and a dispenser pouch formed from flexible laminate sheets. Further, a process for manufacturing the two-phase pharmaceutical delivery system is described including the filling the bi-phasic pharmaceutical composition into flexible dispenser pouches, which allows the patient to squeeze and dispense the contents of the package directly into the oral cavity. |
申请公布号 |
EP2768488(A4) |
申请公布日期 |
2015.04.15 |
申请号 |
EP20120842547 |
申请日期 |
2012.10.05 |
申请人 |
R.P. SCHERER TECHNOLOGIES, LLC |
发明人 |
MAIER, HANS JÜRGEN |
分类号 |
A61K9/06;A61K9/50;A61K31/196 |
主分类号 |
A61K9/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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