A syringe for use in a pharmaceutical delivery system is described. The syringe is a dual zone syringe having a working zone including a fluid reservoir at a distal end of the syringe and a non-working zone configured to receive a slidable plunger assembly, an a plunger having a proximal end to contact a piston and a distal end having a shape similar to the distal end of the syringe. The plunger comprises a distal seal and a proximal seal, where the distal seal seals the working zone and the proximal seal seals the non-working zone.
