| 主权项 |
1. A method of treating cancer, said method comprising administering to a mammalian subject in need thereof a pharmaceutically effective amount of a microcystin which is not microcystin LR, wherein the cancer comprises cancer cells that express at least one of OATP1B1 and OATP1B3 and the microcystin has improved cytotoxicity for the cells expressing at least one of OATP1B1 and OATP1B3 as compared to microcystin LR, wherein the cancer is selected from the group consisting of gastrointestinal cancer, lung cancer, gastric cancer, colon cancer, pancreatic cancer, gall bladder cancer, breast cancer and glioblastoma; wherein said microcystin has the following formula:
cyclo (D-Ala-X-erythro-β-methyl-D-iso-Asp-Y-adda-D-iso-Glu-N-methyldehydro-Ala) wherein X is leucine and Y is phenylalanine (MCLF) or tryptophan (MCLW). |
