Chain-end functionalized poly(ethykene oxide) and process for the preparation of a nano-sized transition metal or metal salt using the same

摘要

There is provided a novel chain-end functionalized PEO of formulas (I) to (IV) prepared via living anionic polymerization and chain-end functionalization, as well as a simple method of preparing nano-sized transition metal or metal salt particles using the same, which can be readily stabilized even in an aqueous medium. The water-soluble PEO-based polymers having various functional groups (including a drug group such as vitamin and anti-cancer agent) and the process of preparing nano-sized transition metal or metal salt particles using the same can be advantageously used in the development of new materials for drug delivering system and imaging, e.g., a contrast agent and an anti-cancer agent simultaneously.

主权项

1. A nano-particle of a transition metal or salt thereof wherein the transition metal or salt thereof is encapsulated inside a micelle formed by a poly (ethylene oxide) (PEO) having a functionalized chain end selected from the group consisting of compounds of formula (II) wherein, R is methyl, n-butyl, sec-butyl or tert-butyl, Y is a sulfonamide group selected from the group consisting of sulfabenzene, sulfisoxazole, sulfacetamide, sulfamethizole, sulfadimethoxine, sulfadiazine, sulfamethoxy pyridazine, sulfamethazine, sulfisoimidine, sulfapyridine, indisulam and amprenavir; or vancomycin, and n is an integer in the range of 10 to 500.