| 发明名称 | Immediate release composition resistant to abuse by intake of alcohol | ||
| 摘要 | The present invention relates to immediate release pharmaceutical compositions for oral administration that are resistant to abuse by intake of alcohol. In particular, this disclosure provides immediate release pharmaceutical compositions comprising a polyglycol having a molecular weight of from about 900 to about 17,000 daltons, a drug substance, one or more effervescent agents, and, optionally, one or more disintegrants, such that the composition is formulated to be resistant to abuse by intake of alcohol. | ||
| 申请公布号 | US9005660(B2) | 申请公布日期 | 2015.04.14 |
| 申请号 | US201012701248 | 申请日期 | 2010.02.05 |
| 申请人 | Egalet Ltd. | 发明人 | Tygesen Peter Holm;Oevergaard Jan Martin;Oestman Joakim |
| 分类号 | A61K9/46;A61K9/16;A61K31/44;A61K31/16;A61K31/485;A61K31/167;A61K9/28;A61K9/20 | 主分类号 | A61K9/46 |
| 代理机构 | Foley & Lardner LLP | 代理人 | Foley & Lardner LLP |
| 主权项 | 1. An immediate release pharmaceutical composition, wherein the composition is resistant to alcohol-induced dose dumping, the composition comprising: a. one or more drug substances; and b. a polymer matrix resistant to alcohol-induced dose dumping, wherein the drug substance is dispersed within the polymer matrix, and wherein the polymer matrix consists essentially of (i) a polyglycol having a molecular weight of from 900 to about 17,000 Daltons; (ii) one or more effervescent agents; and (iii) one or more disintegrants. | ||
| 地址 | London GB | ||