发明名称 |
Activated nitric oxide donors and methods of making and using thereof |
摘要 |
Described herein are compositions useful in anticancer treatment and prevention. The compositions are composed of (a) an O2-aryl substituted diazeniumdiolate and (b) an amphiphile, wherein the amount of amphiphile is sufficient to produce a liposome or micelle. The compositions described herein provide numerous advantages such as increased solubility and stability of the O2-aryl substituted diazeniumdiolate in vivo. The compositions also do not induce hypotension. Methods for using the compositions in anticancer treatment and prevention are also described herein. |
申请公布号 |
US9005656(B2) |
申请公布日期 |
2015.04.14 |
申请号 |
US200912921227 |
申请日期 |
2009.03.05 |
申请人 |
University of Utah Research Foundation |
发明人 |
Shami Paul J.;Kosak Ken M. |
分类号 |
A61K9/127;A61K31/56;A61K31/655;A61K9/107 |
主分类号 |
A61K9/127 |
代理机构 |
Gardner Groff Greenwald & Villanueva, PC |
代理人 |
Gardner Groff Greenwald & Villanueva, PC |
主权项 |
1. A composition produced by the process comprising admixing
(a) O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate (JS-K) or the pharmaceutically acceptable salt or ester thereof; and (b) a poloxamer having the formula
HO(C2H4O)b(C3H6O)a(C2H4O)bH wherein a is from 50 to 80 and b is from 10 to 25, wherein the amount of poloxamer is sufficient to produce a micelle. |
地址 |
Salt Lake City UT US |