发明名称 |
PROCESS FOR THE PREPARATION OF A HOT-MELT EXTRUDED LAMINATE |
摘要 |
<p>A process for the preparation of a bioadhesive laminate comprising a hot-melt extruded reservoir layer and a hot-melt extruded backing layer is provided. The reservoir layer comprises a thermoplastic bioadhesive composition containing an active agent. An active agent-containing thermoplastic bioadhesive hydrophilic composition is hot-melt coextruded with a hydrophobic composition to form at least a bi-layered laminate. The hydrophilic composition and the hydrophobic composition have at least one polymer in common. In addition, the melt flow index of the hydrophobic composition is within 50% of the melt flow index of the hydrophilic composition. As a result, the laminate has a uniform transverse cross-section and/or a uniform longitudinal cross-section throughout a major of the length of the laminate. Moreover, when the laminate is divided into unit doses of approximately the same size, they have a high degree of content uniformity with respect to the active agent(s) present therein.</p> |
申请公布号 |
CA2647801(C) |
申请公布日期 |
2015.04.14 |
申请号 |
CA20072647801 |
申请日期 |
2007.03.22 |
申请人 |
AUXILIUM PHARMACEUTICALS, INC. |
发明人 |
CROWLEY, MICHAEL M.;KEEN, JUSTIN M.;KOLENG, JOHN J.;ZHANG, FENG |
分类号 |
B29C47/06;A61K9/14;A61K9/32;A61K9/58;B29C47/00;B61F13/00 |
主分类号 |
B29C47/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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