| 发明名称 | Genetically modified heart valve xenografts | ||
| 摘要 | A method for producing a heart valve xenograft from bovine tissue expressing reduced or undetectable levels of I1-3 galactosyl transferase are provided. | ||
| 申请公布号 | US9006510(B2) | 申请公布日期 | 2015.04.14 |
| 申请号 | US200712306186 | 申请日期 | 2007.06.12 |
| 申请人 | Mayo Foundation for Medical Education and Research | 发明人 | Byrne Guerard W.;McGregor Christopher G. A. |
| 分类号 | G01N33/00;A01K67/033;C12N9/10;A61K35/34;A61K35/12 | 主分类号 | G01N33/00 |
| 代理机构 | Fish & Richardson P.C. | 代理人 | Fish & Richardson P.C. |
| 主权项 | 1. A method for providing a patient with a xenograft, said method comprising implanting into the heart of said patient a fixed bovine heart valve xenograft, wherein cells of said xenograft, prior to being fixed, contain a homozygous disruption in the endogenous α1-3 galactosyl transferase nucleic acid sequence and do not express α1-3 galactosyl transferase. | ||
| 地址 | Rochester MN US | ||