| 发明名称 | Antikine antibodies that bind to multiple CC chemokines | ||
| 摘要 | An antikine antibody binds to two, three, four, five or more CC chemokines, such as RANTES/CCL5, MIP-1α/CCL3, MIP-1β/CCL4, or MCP-1/CCL2. Methods for affinity maturation and humanization of antikine antibodies as well as the production of hybridoma cell lines producing antikine antibodies by sequential immunization are also disclosed. | ||
| 申请公布号 | US9005617(B2) | 申请公布日期 | 2015.04.14 |
| 申请号 | US201213657120 | 申请日期 | 2012.10.22 |
| 申请人 | Regeneron Pharmaceuticals, Inc. | 发明人 | Allison Dan;Raport Carol |
| 分类号 | A61K39/395;C07K16/24;C07K16/46 | 主分类号 | A61K39/395 |
| 代理机构 | Merchant & Gould PC | 代理人 | Mallon Veronica;Merchant & Gould PC |
| 主权项 | 1. An isolated antibody or antigen binding fragment thereof that binds to at least CCL3/MIP-1α, CCL4/MIP-1β, and CCL4/RANTES chemokines, wherein the antibody comprises the three heavy chain CDRs (HCDR1, HCDR2, and HCDR3) contained within the heavy chain variable region sequence selected from SEQ ID NOS:2, 12, 22, 32, 42, 52, or 62. | ||
| 地址 | Tarrytown NY US | ||