| 摘要 |
<p>The present invention relates to spiro-lactam compounds and pharmaceutical compositions thereof, which are inhibitors of 11.beta. hydroxyl steroid dehydrogenase type 1 (11.beta.HSD1). Compounds of the invention may therefore be used for the treatment of various diseases associated with expression or activity of 11.beta.HSD1, such as obesity, diabetes, glucose intolerance, insulin resistance, hyperglycemia, atherosclerosis, hypertension, hyperlipidemia, cognitive impairment, dementia, depression, glaucoma, cardiovascular disorders, osteoporosis, inflammation, metabolic syndrome, coronary heart disease, type 2 diabetes, hypercortisolemia, androgen excess and polycystic ovary syndrome.</p> |
