| 发明名称 | Hybridoma cell line for producing antibody for type II collagen | ||
| 摘要 | The present invention provides a hybridoma cell line (DSM ACC3145), wherein the hybridoma cell line produces an antibody which specifically binds to an amino acid sequence of type II collagen comprising: K-G-E-P-G-D-D-G-P-S-C (as set forth in SEQ ID NO. 1); and a method for detecting osteoarthritis, by identifying a presence of type II collagen in a urine sample through containing the urine sample with the said antibody. | ||
| 申请公布号 | US9005912(B2) | 申请公布日期 | 2015.04.14 |
| 申请号 | US201213562123 | 申请日期 | 2012.07.30 |
| 申请人 | I-Shou University | 发明人 | Hung Chih-Hsin;Shen Chi-Yen;Kuo Shyh-Ming;Chen I-Fen;Wang Shih-Han |
| 分类号 | C07K16/18;G01N33/68;G01N33/543;C07K14/78 | 主分类号 | C07K16/18 |
| 代理机构 | Muncy, Geissler, Olds & Lowe, P.C. | 代理人 | Muncy, Geissler, Olds & Lowe, P.C. |
| 主权项 | 1. A method for detecting osteoarthritis, comprising the steps of: identifying the presence of unwound type II collagen or fragments thereof in a urine sample by contacting the urine sample with an antibody produced by the hybridoma cell line deposited at DSMZ-Deutsche Sammlung von Mikroorganismen and Zellkulturen with deposit number DSM ACC3145; and detecting binding by the antibody, wherein the presence of unwound type II collagen or fragments thereof in the urine sample indicates osteoarthritis. | ||
| 地址 | Kaohsiung TW | ||