Method for controlling hair growth, method for selecting or evaluating hair growth control agent, and hair growth suppression agent

摘要

The present invention provides a method for controlling hair growth, a method for selecting or evaluating a hair growth control agent, and a hair growth suppression agent. The present invention provides a method for selecting or evaluating a hair growth control agent, including the steps of administering a test substance to a cell capable of expressing DnaJC6; measuring the expression of DnaJC6 in the cell; and evaluating the controlling effect of the test substance on hair growth based on the expression. The present invention also provides a hair growth suppression agent containing funabarasou (Cynanchum atratum) or its extract as the active ingredient.

主权项

1. An in vitro method for selecting or evaluating a hair growth control agent, comprising the following steps (A) to (E):
(A) selecting cells capable of expressing human DnaJC6; (B) subjecting a group of the cells to the presence of a test substance and not subjecting another group of the cells to the presence of the test substance; (C) measuring the expression level of DnaJC6 in both the cells that were subjected to the presence of the test substance and the cells that were not subjected to the presence of the test substance; (D) comparing the expression level of DnaJC6 in the cells that were subjected to the presence of the test substance and in the cells that were not subjected to the presence of the test substance; and (E) selecting the test substance as a hair growth control agent when there is a statistically significant difference in the expression level of DnaJC6 between the cells that were subjected to the presence of the test substance and the cells that were not subjected to the presence of the test substance, wherein a test substance that reduces the expression level of DnaJC6 is selected as a hair growth suppression agent and a test substance that increases the expression level of DnaJC6 is selected as a hair growth promoting agent.