发明名称 |
Variable color two-photon fluorescent probe, method for imaging thiol activation in mitochondrion using same, and method for manufacturing the variable color two-photon fluorescent probe |
摘要 |
The present invention relates to a two-photon fluorescent probe, more particularly a two-photon fluorescent probe represented by Formula 1, a method for preparing same and a method for imaging thiols in mitochondria using same. The two-photon fluorescent probe according to the present invention, having two probes introduced in one molecule, can selectively dye mitochondria and emit intense fluorescence by reacting with thiols. Accordingly, it can be used to image the distribution and activation of thiols in a living cell or an intact living tissue. |
申请公布号 |
US9005917(B2) |
申请公布日期 |
2015.04.14 |
申请号 |
US201114118053 |
申请日期 |
2011.10.17 |
申请人 |
Ajou University Industry-Academic Cooperation Foundation |
发明人 |
Kim Hwan Myung |
分类号 |
C07F9/653;C07F9/6539;G01N33/50;G01N33/58;C07D235/18;C07D263/58;C07D277/68 |
主分类号 |
C07F9/653 |
代理机构 |
Lowe Hauptman & Ham, LLP |
代理人 |
Lowe Hauptman & Ham, LLP |
主权项 |
1. A two-photon fluorescent probe represented by Formula 1: wherein X is S or O. |
地址 |
Suwon-Si, Gyeonggi-Do KR |