发明名称 System and method for determining hematocrit insensitive glucose concentration
摘要 Described are methods and systems to apply a plurality of test voltages to the test strip and measure at least a current transient output resulting from an electrochemical reaction in a test chamber of the test strip so that a glucose concentration can be determined that are generally insensitive to other substances in the body fluid sample that could affect the precision and accuracy of the glucose concentration.
申请公布号 US9005426(B2) 申请公布日期 2015.04.14
申请号 US201213630334 申请日期 2012.09.28
申请人 Cilag GmbH International 发明人 Malecha Michael
分类号 G01N27/327;A61B5/145 主分类号 G01N27/327
代理机构 代理人
主权项 1. A method of determining blood glucose concentration with a glucose measurement system that comprises a test strip and test meter, the test meter having a microcontroller configured to apply a plurality of test voltages to the test strip and measure at least a current transient output resulting from an electrochemical reaction in a test chamber of the test strip, the method comprising: inserting the test strip into a strip port connector of the test meter to connect at least two electrodes coupled to the test chamber of the test strip to a strip measurement circuit; initiating a test sequence after deposition of a sample, in which the initiating comprises: applying a first voltage of approximately ground potential to the test chamber for a first duration;applying a second voltage to the test chamber for a second duration after the first duration;changing the second voltage to a third voltage different from the second voltage for a third duration after the second duration;switching the third voltage to a fourth voltage different from the third voltage for a fourth duration after the third duration;altering the fourth voltage to a fifth voltage different from the fourth voltage for a fifth duration after the fourth duration;modifying the fifth voltage to a sixth voltage different from the fifth voltage for a sixth duration after the fifth duration;changing the sixth voltage to a seventh voltage different from the sixth voltage for a seventh duration after the sixth duration, wherein each of the second to seventh voltages comprises about one millivolt; measuring at least one of: a first current transient output from the test chamber during a first interval proximate the second and third durations;a second current transient output during a second interval proximate the fourth and fifth durations;a third current transient output during a third interval proximate the fifth and sixth durations;a fourth current transient output during a fourth interval proximate the sixth and seventh durations; anda fifth current transient output during a fifth interval proximate the end of the seventh durations; calculating a glucose concentration of the sample from at least one of the first, second, third, fourth, or fifth current outputs such that bias in the glucose concentration is less than ±10% for glucose concentrations less than 75 mg/dL in hematocrits ranging from about 20% to about 60%.
地址 Zug CH