Compositions and methods for cancer diagnosis and therapy

摘要

The miR15 and miR16 micro RNA genes are located at 13q14 within a 30 kb region of loss characteristic of cells from certain cancers, such as cells from chronic lymphocytic leukemia or prostate cancer. Chronic lymphocytic leukemia or prostate cancer can be diagnosed by detecting a reduction in miR15 or miR16 gene copy number, by determining miR15 or miR16 gene mutational status, or by detecting a reduction in the RNA transcribed from these genes. The miR15 or miR16 gene products can inhibit the neoplastic or tumorigenic growth of cancers such as chronic lymphocytic leukemia or prostate cancer cells when administered to subjects suffering from these diseases.

主权项

1. A method of treating a prostate cancer in a subject in need of such treatment, comprising administering to the subject an effective amount of an isolated nucleic acid encoding a miR15 gene product, wherein proliferation of prostate cancer cells in the subject is inhibited.