Inorganically surface-modified polymers and methods for making and using them

摘要

In alternative embodiments, the invention provides articles of manufacture comprising biocompatible nanostructures comprising PolyEther EtherKetone (PEEK) surface-modified (surface-nanopatterned) to exhibit nanostructured surfaces that promote osseointegration and bone-bonding for, e.g., joint (e.g., knee, hip and shoulder) replacements, bone or tooth reconstruction and/or implants, including their use in making and using artificial tissues and organs, and related, diagnostic, screening, research and development and therapeutic uses, e.g., as primary or ancillary drug delivery devices. In alternative embodiments, the invention provides biocompatible nanostructures that promote osseointegration and bone-bonding for enhanced cell and bone growth and e.g., for in vitro and in vivo testing, restorative and reconstruction procedures, implants and therapeutics.

主权项

1. A product of manufacture comprising an internal cavity having an inner wall and an outer wall, the product of manufacture further comprising:
(a) a thermoplastic polymer comprising a plurality of nano-imprints, wherein at least a portion of the plurality of nano-imprints are formed using a pair of nano-imprint stamps, wherein the first of the pair of nano-imprint stamps faces the inner wall and the second of the pair of nano-imprint stamps faces the outer wall, wherein at least a portion of the plurality of nano-imprints each have a re-entrant pore geometry that is formed using a process comprising a warm compression of the thermoplastic polymer; and (b) a biocompatible surface layer deposited on at least a portion of the thermoplastic polymer, wherein the biocompatible surface layer comprises any of a metal, a metal alloy, a stainless steel, and a ceramic, wherein the biocompatible surface layer includes a plurality of nanotubular structures that each have a diameter of approximately 5 to 1000 nanometers (nm).