Compositions, methods and uses for poxvirus elements in vaccine constructs against influenza virus subtypes or strains

摘要

Embodiments of the present invention generally disclose methods, compositions and uses for generating and expressing poxvirus constructs. In some embodiments, constructs may contain an influenza virus gene segment. In certain embodiments, methods generally relate to making and using compositions of constructs including, but not limited to, poxvirus vaccine compositions having two or more influenza gene segments. In other embodiments, vaccine compositions are reported of use in a subject.

主权项

1. A construct comprising:
a modified vaccinia virus construct encoding at least one vaccinia virus secretory signal sequence associated with a first influenza protein, and at least a second influenza protein; wherein the at least one vaccinia virus secretory signal sequence comprises, at least one of a secretory signal sequence of C13L or B8R; wherein the influenza proteins in the construct are capable of inducing an immune response in a subject.