| 发明名称 | Genetically modified human umbilical cord perivascular cells for prophylaxis against or treatment of biological or chemical agents | ||
| 摘要 | The invention provides methods of preventing or treating diseases or disorders caused by biological agents or chemical agents in a subject (e.g., a mammal, such as a human) by administering genetically modified human umbilical cord perivascular cells. | ||
| 申请公布号 | US9005599(B2) | 申请公布日期 | 2015.04.14 |
| 申请号 | US200912988909 | 申请日期 | 2009.04.20 |
| 申请人 | Tissue Regeneration Therapeutics Inc. | 发明人 | Ennis Jane Elizabeth;Turner Jeffrey Donald;Davies John Edward |
| 分类号 | A61K38/20;A61K35/12;C12N5/071;A61K39/00;A61K38/21;A61P37/04;A61P37/06;C07K14/56;A61K35/44;A61K39/12;C07K16/10;C12N5/073;C12N5/0775 | 主分类号 | A61K38/20 |
| 代理机构 | Clark & Elbing LLP | 代理人 | Clark & Elbing LLP ;Clark, Esq. Paul T.;Armstrong Todd |
| 主权项 | 1. A method for treating or protecting a human subject exposed to a chemical agent comprising administering to the subject a composition comprising an isolated cell population comprising human umbilical cord perivascular cells (HUCPVCs) having a 3G5+, CD45−, CD44+ phenotype, wherein the cell population is characterized by rapid proliferation and the presence of human progenitor cells, and the HUCPVCs in said cell population are genetically modified to express a butyrylcholinesterase (BChE) polypeptide or to increase the expression of an endogenous butyrylcholinesterase (BChE) polypeptide, and wherein said composition treats or protects said subject exposed to said chemical agent. | ||
| 地址 | Toronto CA | ||