Substituted cyclopentanes having prostaglandin activity

摘要

Disclosed herein are compounds having a formula:;
Therapeutic methods, medicaments, and compositions related thereto are also disclosed.

主权项

1. A compound having the formula:wherein:
Y is —Cl, —F, —CN, or —CF3; R is H, or R consists of: 1) C1-6 alkyl or phenyl, and 2) from 0 to 2 —OH moieties; the dashed line indicates the presence or absence of a bond; the wavy line indicates a cis or a trans configuration; R2 is —CH2CH3, —CH2CH2OH, or —CH═CH2; and t is 0, 1, 2, 3, 4, or 5.