Compounds and methods for treatment of hypertension

摘要

Hydrogenated pyrido[4,3-b]indoles, pyrido[3,4-b]indoles and azepino[4,5-b]indoles are described. The compounds may bind to and are adrenergic receptor α2B antagonists. The compounds may also bind to and antagonize adrenergic receptor α1B. The compounds may find use in therapy, e.g., to (i) reduce blood pressure and/or (ii) promote renal blood flow and/or (iii) decrease or inhibit sodium reabsorption. The compounds may also be used to treat diseases or conditions that are, or are expected to be, responsive to a decrease in blood pressure. Use of the compounds to treat cardiovascular and renal disorders is particularly described.

主权项

1. A method of lowering blood pressure in an individual in need thereof comprising administering to the individual an effective amount of a compound selected from the group consisting of Compound Nos. 6, 9 to 12, 14, 16 to 21, 23 to 28, 39 to 40, 42, 44 to 59, 63 to 72, 77 to 82, 104, 108 to 116, 118 to 131, 133 to 142, 144 to 171, 173 to 179, 187 to 192, 195 to 198, 220, 269 to 271, 273 to 287, 290 to 306, 308 to 319, 321 to 338, 340 to 342, II-1 to II-4, II-6 to II-16, II-18 to II-19, II-39 to II-40, II-58 to II-65, II-67 to II-68, II-70 to II-71, II-75 to II-77, II-80 to II-84, II-88 to II-94, II-96 to II-106, II-108 to II-118, II-120 to II-121, II-123 to II-125, II-127 to II-128, II-130 to II-136, II-138 to II-154, II-188 to II-206, II-212 to II-213, II-215, II-220 to II-227, II-229 to II-232, II-240, II-243 to II-253, II-255 to II-269, II-271 to II-272, II-274, II-276 to II-285, II-287 to II-291, II-293 to II-298, IV1, IV-8 to IV-9, IV-11 to IV-18, IV-49 to IV-58, IV-91, IV-93 to IV-98, IV129 to IV-138, IV-169 to IV-178, IV-209 to IV-211, IV-213 to IV-218, and V-1 to V-23; or a salt, solvate or N-oxide thereof.