FREMGANGSMÅDE TIL FREMSTILLING AF 2,2-DIFLUORETHYLAMIN-DERIVATER GÅENDE UD FRA N-(2,2-DIFLUORETHYL)PROP-2-EN-1-AMIN

摘要

Process for the preparation of 2,2-difluoroethylamine derivatives of the formula (IV) comprising the steps (i) and (ii): step (i): reaction of N-(2,2-difluoroethyl)prop-2-en-1-amine of the formula (I) with a compound of the formula (II) A-CH2-E(II) to give a compound of the formula (III) optionally in the presence of an inorganic or organic base, and step (ii): removal of the allyl group from the compound of the formula (III), in which, in the formulae (II), (III) and (IV), A and E have the meanings given in the description.