METHOD OF MANUFACTURING AMORPHOUS OF SODIUM MONTELUKAST

摘要

PROBLEM TO BE SOLVED: To provide a method of efficiently manufacturing 1-(((1R)-(3-(2(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methyl ethyl)phenyl)propyl)thio)methyl)cyclopropane sodium acetate having reduced residual solvent content.SOLUTION: A solution which 1-(((1R)-(3-(2(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methyl ethyl)phenyl)propyl)thio)methyl)cyclopropane sodium acetate is solved in at least one kind selected from a group consisting of aromatic hydrocarbons and acetic acid esters is dropped in an aliphatic hydrocarbon having 5 to 8 carbon atoms at -10°C to 10°C to be immobilized.