METHOD FOR PRODUCING PENICILLIN MICROCAPSULES IN KAPPA-CARAGEENAN

摘要

FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to microencapsulation, particularly to a method for producing penicillin microcapsules. According to the method, a microcapsule coating is kappa-carageenan; a weighed amount of kappa-carageenan in acetone is added with a drug powder in the presence of the surfactant E472c; the drug to kappa-carageenan ratio at a dry basis makes from 1:1 to 1:3; after an independent solid phase is formed, carbinol 5 ml and distilled water 1 ml are added very slowly drop by drop; the prepared suspension of the microcapsules is filtered, washed and dried; the encapsulation process takes 15 minutes.EFFECT: method provides simplifying and accelerating the penicillin microencapsulation in kappa-carageenan.6 ex