FENBENDAZOLE ENCAPSULATION METHOD

摘要

FIELD: chemistry.SUBSTANCE: invention relates to encapsulation, particularly a method of producing fenbendazole microcapsules in a sodium carboxymethyl cellulose capsule. The method includes dissolving fenbendazole in dioxane or dimethyl sulphoxide or dimethyl formamide, adding the obtained fenbendazole solution to a solution of sodium carboxymethyl cellulose in tetrachloromethane in the presence of E472c while stirring at a rate of 1000 rps. Fenbendazole and sodium carboxymethyl cellulose are taken in weight ratio of 1:3. Methanol and distilled water, taken in ratio of 2:1 vol/vol, are then added. The obtained suspension of microcapsules is filtered and dried. The process is carried out at 25°C for 20 minutes.EFFECT: invention simplifies and speeds up the process of producing microcapsules, reduces losses during production thereof (high mass output).3 ex