NANOCRYSTALS OF NARINGIN AND ITS PREPARATION

摘要

The present invention provides naringin nanocrystals characterized by: i) particle size ranges from 200 to 280 nm; ii) PDI ranging from 0.300 to 0.320; zeta potential ranging from -35.75 to -38.8 mV; and 1.5 fold increased saturation solubility compare to pure naringin. The present invention also provides a process for the preparation of nanocrystals of naringin which involves dispersing naringin and at least one stabilizer in a solvent to obtain dispersion; drying said dispersion to evaporate the solvent to obtain a residue of naringin-stabilizer; hydrating said residue using water followed by homogenizing to obtain a homogeneous suspension; sonicating said suspension to obtain a nanosuspension; and lyophilizing said nanosuspension to obtain the nanocrystals of naringin.