Methods and Systems To Identify Phase-Locked High-Frequency Oscillations In The Brain

摘要

Method and device for the automatic identification of phase-locked high-frequency oscillations (PLHFO) to localize epileptogenic brain for neurosurgical intervention, including filtering brain signals into low frequency and high frequency oscillation (HFO) data streams. Applying ICA to the HFO data stream, transforming the data streams to produce an HFO instantaneous amplitude (HFOIA) and a low-frequency instantaneous phase (LFIP) data stream. Transforming the normalized HFOIA to produce an instantaneous phase of the normalized HFOIA. Determining a continuous or discrete PLHFO calculation that measures cross frequency coupling between the instantaneous phase of the low frequency data stream, and the instantaneous amplitude of the HFO data stream based at least in part on LFIP, raw or normalized HFOIA, and may include the instantaneous phase of normalized or raw HFOIA. Determining that at least a portion of the electrical signals from the brain display PLHFO if the PLHFO calculation is above a statistical threshold.

主权项

1. A method for identifying brain electrical activity displaying phase-locked high-frequency oscillations (PLHFO), comprising:
receiving electrical signals from the brain; filtering the electrical signals to produce a high frequency oscillation (HFO) data stream and a low-frequency data stream; applying independent component analysis to the HFO data stream and removing noise from the HFO data stream; transforming each of the HFO data stream and the low-frequency data stream to produce an HFO instantaneous amplitude and a low-frequency instantaneous phase; normalizing the HFO instantaneous amplitude to produce a normalized HFO instantaneous amplitude; transforming the normalized HFO instantaneous amplitude to produce an instantaneous phase of the normalized HFO instantaneous amplitude; determining a PLHFO calculation based at least in part on the low-frequency instantaneous phase, the normalized HFO instantaneous amplitude, and the instantaneous phase of the normalized HFO instantaneous amplitude; and determining that at least a portion of the electrical signals from the brain displaying PLHFO if the PLHFO calculation is above a threshold