发明名称 |
Methods and Compositions For Detecting Mutation in the Human EZH2 Gene |
摘要 |
The invention comprises reagents and methods for detecting cancer-associated mutations in the human EZH2 gene. Further, a method of detecting the mutations and a method of treatment are disclosed. |
申请公布号 |
US2015099747(A1) |
申请公布日期 |
2015.04.09 |
申请号 |
US201414508618 |
申请日期 |
2014.10.07 |
申请人 |
Roche Molecular Systems, Inc. |
发明人 |
Ma Xiaoju Max;Manohar Chitra;Tsan Alison |
分类号 |
C12Q1/68;A61K31/5377;A61K31/496;A61K31/4439 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
1. An isolated oligonucleotide for detecting mutations in the human EZH2 gene consisting of the sequence of an oligonucleotide selected from SEQ ID NOs corresponding to EZH2_Y646N_R (SEQ ID NO: 1), Y646H_R (SEQ ID NO: 12), Y646F_R (SEQ ID NO: 21), Y646C_R (SEQ ID NO: 41), A682G_R (SEQ ID NO: 59) and A692V_R (SEQ ID NO: 73) except comprising at least one mismatch with the naturally occurring sequences of the human EZH2 gene. |
地址 |
Pleasanton CA US |