APREPITANT ORAL LIQUID FORMULATIONS

摘要

A liquid pharmaceutical compositions comprising Aprepitant is preferably prepared as an oral suspension dosage form for the prevention and control of acute and delayed chemotherapy induced nausea and vomiting, and/or for prevention of postoperative nausea and vomiting.

主权项

1. A method of producing a stabilized aqueous suspension of aprepitant for oral administration, the method comprising:
combining a pharmaceutically effective amount of aprepitant particles, a cellulosic stabilizer, and an anionic surfactant with an acidic aqueous buffer to form a stabilized aqueous suspension; wherein the aprepitant particles have an average particle size of less than 0.5 micron; wherein the cellulosic stabilizer and the anionic surfactant are present in an amount effective that limits growth of the aprepitant particles in the stabilized aqueous suspension to equal or less than 20% within a month at ambient conditions; and packaging the stabilized aqueous suspension in a form suitable for oral administration.