Modulators of ACYL-COA Lysocardiolipin Acyltransferase 1 (ALCAT1) and Uses Thereof

摘要

Compositions of modulators of acyl-CoA lysocardiolipin acyf transferase 1 (ALCAT1) expression, function or activity are provided. In particular, inhibitors of ALCAT1 are useful in treating metabolic diseases, cardiac diseases and, in general diseases associated with mitochondrial dysfunction. Assays for identification of novel ALCAT1 modulators are provided.

主权项

1. A method of identifying a modulator of acyl-CoA lysocardiolipin acyltransferase 1 (ALCAT1) expression, function or activity, comprising:
contacting a biological sample with a test agent; measuring expression, function or activity of a mitofusin molecule in the biological sample, wherein a test agent is identified as an inhibitor of ALCAT1 expression, function or activity if the agent increases the expression, function or activity of a mitofusin MFN2 molecule as compared to a baseline control and ALCAT1 expression, function or activity is substantially decreased as compared to a normal baseline control; or, measuring expression, function or activity of ALCAT1 molecules in the biological sample wherein a test agent is identified as a modulator of ALCAT1 expression, function or activity if the agent modulates the expression, function or activity of the ALCAT1 molecules as compared to a baseline control; thereby, identifying a modulator of acyl-CoA lysocardiolipin acyltransferase 1 (ALCAT1).