ANTIMICROBIAL AND ANTIFOULING CATECHOL-CONTAINING POLYCARBONATES FOR MEDICAL APPLICATIONS

摘要

Catechol-bearing polycarbonates (catechol polymers) were prepared comprising i) a catechol repeat unit comprising a side chain catechol group, ii) a cationic repeat unit comprising a side chain cationic group selected from the group consisting of quaternary amine groups, quaternary phosphine groups, and combinations thereof, and iii) a PEG repeat unit comprising a side chain poly(ethylene oxide) group having a degree of polymerization of about 5 to about 30. The catechol polymers form antimicrobial and antifouling films on a variety of substrate surfaces, in particular silicone rubber.

主权项

1. A polycarbonate, comprising:
a catechol repeat unit comprising i) an aliphatic carbonate backbone portion and ii) a side chain linked to the backbone portion, the side chain comprising a catechol group of formula (A-1): wherein a′ is an integer of 0 to 3, and each R′ is an independent monovalent radical selected from the group consisting of halogens, methyl, and ethyl.