发明名称 |
NOVEL APPROACH FOR SYNTHESIS OF CATECHINS |
摘要 |
A process for synthesis of enatiomerically pure or enatiomerically enriched or racemic mixture of (+and/or-) epicatechin and its intermediates, comprising the steps of: (i) obtaining penta-protected quercetin; (ii) reducing the penta-protected quercetin obtained from step (i); (iii) optionally deprotecting the compound of step (ii); (iv) reducing the compound obtained from step (ii) or step (iii) in the presence of a chiral/achiral reducing agent to obtain a chiral intermediate; (v) deprotecting and/or hydrogenation of the chiral intermediate obtained from step (iv) to obtain (-)-epicatechin; (vi) optionally simultaneously deprotecting and hydrogenation of the compound obtained from step (ii) to obtain racemic epicatechin. |
申请公布号 |
WO2014115174(A8) |
申请公布日期 |
2015.04.09 |
申请号 |
WO2014IN00061 |
申请日期 |
2014.01.27 |
申请人 |
SPHAERA PHARMA PVT. LTD. |
发明人 |
DUGAR, SUNDEEP;MAHAJAN, DINESH;RAI, KUMAR, SANTOSH;TRIPATHI, VINAYAK;PATIL, ISHWAR, RAKESH |
分类号 |
C07D311/62;C07D311/64;C07H15/26 |
主分类号 |
C07D311/62 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|