发明名称 |
ENZALUTAMIDE IN COMBINATION WITH AFURESERTIB FOR THE TREATMENT OF CANCER |
摘要 |
A novel combination comprising an androgen receptor inhibitor, for example: 4- (3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2- fluoro-N-methylbenzamide or a pharmaceutically acceptable salt thereof, and an AKT inhibiting compound, for example: N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5- chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide, or a pharmaceutically acceptable salt thereof, and optional additional antineoplastic agents; pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which androgen receptor inhibition and/or AKT inhibition is beneficial, e.g., cancer. |
申请公布号 |
WO2015049650(A1) |
申请公布日期 |
2015.04.09 |
申请号 |
WO2014IB64997 |
申请日期 |
2014.10.01 |
申请人 |
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED |
发明人 |
CORNFELD, MARK J.;KUMAR, RAKESH;MORRIS, SHANNON RENAE |
分类号 |
A61K31/4155;A61K31/4166;A61K31/58;A61K45/06;A61P35/00;A61P35/02 |
主分类号 |
A61K31/4155 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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