T CELL-INDUCING VACCINE CONTAINING INTEREPITOPE SEQUENCE PROMOTING ANTIGEN PRESENTATION

摘要

The purpose of the present invention is to provide an interepitope sequence that effectively induces antigen presentation of each epitope in a long-chain peptide antigen having a plurality of epitopes. For this purpose, provided is a vaccine comprising a long-chain peptide antigen having a plurality of epitopes, said vaccine being characterized in that a sequence between the individual epitopes is one sequence selected from the group consisting of 2-10 consecutive tyrosine residues, 2-10 consecutive threonine residues, 2-10 consecutive alanine residues, 2-10 consecutive histidine residues, 2-10 consecutive glutamine residues and 2-10 consecutive asparagine residues. It is preferred that this vaccine is a vaccine selected from the group consisting of an anticancer vaccine, an antibacterial vaccine and an antiviral vaccine. It is also preferred that this vaccine is at least one vaccine selected from the group consisting of a peptide vaccine, a DNA vaccine, an mRNA vaccine and a dendritic cell vaccine.