COMPOSITIONS AND METHODS OF SCREENING FOR COMPOUNDS THAT MODULATE ACTIVITY AT A TWEAK BINDING SITE ON A CRD OF FN14
摘要
The present disclosure is directed to methods of screening a compound for modulating activity at a TNF-like weak inducer of apoptosis (TWEAK) binding site on a cysteine-rich domain (CRD) of fibroblast growth factor-inducible 14 (Fn14). The present disclosure also provides heterocyclic compounds and pharmaceutically acceptable salts thereof and methods for the prevention, treatment, and amelioration of cell proliferative disorders with these compounds.
申请公布号
WO2015006508(A3)
申请公布日期
2015.04.09
申请号
WO2014US46047
申请日期
2014.07.09
申请人
THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE;TRAN, NHAN;MEURICE, NATHALIE;DHRUV, HARSHIL;YIN, HONGWEI