SUBSTITUTED BERBINES AND THEIR SYNTHESIS

摘要

The present invention provides substituted berbines, processes for the synthesis of substituted berbine compounds, as well as intermediates used in the synthesis of substituted berbine compounds. Also provided are methods for using the substituted berbines to inhibit cancer cell growth.

主权项

1. A compound comprising Formula (V-1):wherein:
R1 R2, R3, and R4 independently are hydrogen, halogen, OR15, NR15N16, nitro, cyano, thiol, hydrocarbyl, substituted hydrocarbyl, or together R2 and R3 along with the ring carbons to which they are attached form a ring comprising {−}O(CH2)nO{−}; R5, R6, R7, and R8 independently are hydrogen, halogen, OR15, NR15N16, nitro, cyano, thiol, hydrocarbyl, substituted hydrocarbyl, or together R6 and R7 along with the ring carbons to which they are attached form a ring comprising {−}O(CH2)nO{−}; provided that at least two of R6, R7, and R8 are other than methoxy; R9, R10, R11, and R12 independently are hydrogen, hydrocarbyl, or substituted hydrocarbyl; R21, R22, R23, R24, and R25 independently are hydrogen, halogen, OR15, NR15N16, nitro, cyano, thiol, hydrocarbyl, or substituted hydrocarbyl; R15 and R16 independently are hydrogen, hydrocarbyl, or substituted hydrocarbyl; m is an integer of 0 or greater; n is an integer from 1 to 3; and the dashed lines represent optional double bonds.