IN SITU GEL LOADED WITH PHOSPHODIESTERASE TYPE V INHIBITORS NANOEMULSION

摘要

The in situ gel loaded with phosphodiesterase Type V (PDE5) inhibitors nanoemulsion was prepared using an innovative approach to reformulate the PDE5 inhibitors in a nanoemulsion, and then loading the nanoemulsion into an in situ gel base. These preparations are administered by intramuscular injection in order to give a depot effect for a period of time that exceeds 15 days. The in situ gel composition gives slow, controlled release of the PDE5 inhibitor. The in situ gel composition is useful for prophylaxis and treatment of some important chronic diseases, such as diabetic complications, benign prostatic hyperplasia, erectile dysfunction, and diseases associated with endothelial dysfunction.

主权项

1. A composition for depot slow, controlled release of a PDE5 inhibitor, comprising a nanoemulsion containing an effective amount of at least one phosphodiesterase Type V (PDE5) inhibitor, the nanoemulsion loaded into an in situ gel base comprising an in situ gelling agent,
wherein the effective amount of the at least one PDE5 inhibitor comprises between 20 milligrams and 300 milligrams, and the nanoemulsion comprises a blend of at least one oil, at least one surfactant, and at least one cosurfactant.