Tabletting Process

摘要

A process for producing a compressed solid dosage form containing an active ingredient. The process includes a step of preparing core elements containing the active ingredient. Optionally the core elements are coated with a pharmaceutically acceptable coating layer to form coated pellets. The core elements or pellets are treated with an anti-static agent and compressed with suitable excipients to form the compressed solid dosage form. Particular anti-static agents are starch, microcrystalline cellulose, kaolin, bentonite, silicates, silicon dioxide, cellulose, stearic acid, sodium stearyl fumarate and glyceryl behenate.

主权项

1. A process for producing a compressed solid dosage form containing an active ingredient, the process including:
preparing core elements containing the active ingredient, optionally coating the core elements with a pharmaceutically acceptable coating layer to form coated pellets, treating the core elements or pellets with an anti-static agent, and compressing the treated core elements or pellets with suitable excipients to form the compressed solid dosage form,wherein the hardness of the compressed solid dosage form is greater for a given compression force than an equivalent solid dosage form in which the core elements or pellets have been treated with talc.