Protein ligand for affinity isolation matrix

摘要

The present invention addresses the problem of developing technology for creating new modified protein ligands that maximize binding capacity and binding efficiency to a target molecule when a protein ligand is immobilized in an affinity isolation matrix. The present invention provides a protein ligand (variant) capable of being immobilized on a carrier in the configurations shown in diagrams (4)-(15) of fig.1, and an antibody affinity isolation matrix in which the protein ligand is immobilized on a water-insoluble carrier. The affinity isolation matrix is characterized in that the binding capacity and binding efficiency to a target molecule are superior.