METHOD FOR PRODUCING v-COELENTERAZINE COMPOUND

摘要

PROBLEM TO BE SOLVED: To provide a method for producing a v-coelenterazine compound.SOLUTION: There is provided a method for producing a v-coelenterazine compound represented by the general formula (II), the method comprising: (1) a step of reacting a compound represented by the general formula (VIII) with a methyltriphenylphosphonium salt in the presence of a base to obtain a compound represented by general formula (IX); (2) a step of performing a ring-closing metathesis reaction on any one selected from the group consisting of the compound represented by general formula (IX) and a compound represented by the general formula (X) in which the amino of the compound represented by the general formula (IX) is protected with Rand then deprotecting R4 and R5 when present to obtain a v-coelenteramine compound represented by the general formula (XIV); and (3) a step of reacting the compound represented by the general formula (XIV) with a compound represented by the general formula (XV) to obtain a compound represented by the general formula (II).