发明名称 |
INHIBITORS OF METALLO-BETA-LACTAMASE (MBL) COMPRISING A ZINC CHELATING MOIETY |
摘要 |
The invention provides compounds according to formula I: A - L - B wherein A represents a lipophilic chelating moiety which is selective for Zn2+ ions; L is a covalent bond or a linker; and B is a vector which is either a moiety capable of interacting with one or more biological structures found in a bacterium (preferably in a bacterial cell wall), for example a penicillin-binding protein such as a metallo-β- lactamase or DD-transferase, or a moiety capable of enhancing transport of the compound across a bacterial cell membrane. Such compounds find use in a method of treating and/or preventing a bacterial infection in a human or non-human mammal. In such a method, the compound of formula I may be administered in combination with (either simultaneously, separately, or sequentially) a β-lactam antibiotic. |
申请公布号 |
WO2015049546(A1) |
申请公布日期 |
2015.04.09 |
申请号 |
WO2014GB53009 |
申请日期 |
2014.10.06 |
申请人 |
UNIVERSITETET I OSLO;GOLDING, LOUISE |
发明人 |
RONGVED, PÅL;ÅSTRAND, OVE ALEXANDER HØGMOEN;BAYER, ANNETTE;LEIROS, HANNA-KIRSTI SCHRØDER;SAMUELSEN, ØRJAN;EDVARDSEN, KINE SUSANN WAADE |
分类号 |
A61K47/48;A61P31/04 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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